McCune-Albright Syndrome in a 4-year-old Nigerian child: A case report from the University of Maiduguri Teaching Hospital.

Abstract

McCune-Albright syndrome is a genetic disorder that affects the skin, bones, and endocrine system. It is a mosaic 
disease caused by mutations in the somatic-activating GNAS gene. It is a very rare disease and there are limited 
reports from Nigeria. We therefore present a 4-year-old girl who presented with a 2-month history of cyclical vaginal bleeding, bilateral breast enlargement (Tanner stage 3, with galactorrhea), and a 2-year history of limping. 
Examination revealed café-au-lait macules on the left trunk, axilla, and neck, along with pre-pubertal vaginal 
bleeding (intact hymen, bloodstained vulva). Laboratory findings showed elevated alkaline phosphatase and 
suppressed luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels. A diagnosis of McCune was thus made. This report highlights an African paediatric case of this rare disorder.